A novel peptide interferes with Mycobacterium tuberculosis virulence and survival

A novel peptide interferes with Mycobacterium tuberculosis virulence and survival

Blog Article

Tuberculosis (TB) is a huge global burden, with new and resistant strains emerging at an alarming rate, necessitating an urgent need for a new class of drug candidates.Here, we report that SL3, a novel 33-amino acid peptide, causes debilitating effects on mycobacterial morphology.Treatment with SL3 diegojavierfares.com drastically inhibits the growth of Mycobacterium tuberculosis in vitro cent dyyni as well as in a pre-clinical mouse model for M.tb infection.Microarray analysis of SL3-expressing strain demonstrates wide-scale transcriptional disruption in M.

tb.We therefore believe that SL3 and similar peptides may herald a new approach towards discovering new molecules for TB therapy.